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KMID : 1377020230200050661
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Tissue Engineering and Regenerative Medicine
2023 Volume.20 No. 5 p.661 ~ p.670
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Development of Matrix Metalloproteinases-Mediated Extracellular Matrix Remodeling in Regenerative Medicine: A Mini Review
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Kaiqi Chen
Mimi Xu
Feng Lu
Yunfan He
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Abstract
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Extracellular matrix (ECM) components confer biomechanical properties, maintain cell phenotype and mediate tissue homeostasis. ECM remodeling is complex and plays a key role in both physiological and pathological processes. Matrix metalloproteinases (MMPs) are a group of enzymes responsible for ECM degradation and have been accepted as a key regulator in ECM remodeling. In this mini-review, we summarize MMPs categories, functions and the targeted substrates. We then discuss current understanding of the role of MMPs-mediated events, including inflammation reaction, angiogenesis, cellular activities, etc., in ECM remodeling in the context of regenerative medicine.
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KEYWORD
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Matrix metalloproteinases, ECM remodeling, Regenerative medicine, Matrikines
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